Ameloblastic Carcinoma: A Case Report And Update On Classification System Of Odontogenic Malignancies

Ameloblastic carcinoma is a rare malignant lesion with characteristic behaviour that dictates a more aggressive surgical approach than that of a simple ameloblastoma. However, due to less number of cases reported till now in the literature and scarcity of documentations, reliable evidence of its biologic activity is currently unavailable. Because the lesion is usually found unexpectedly after an incisional biopsy of diagnosed case of Ameloblastoma or after the removal of a cyst, a guide to differential diagnosis is not usually useful. Most ameloblastic carcinomas are presumed to have arisen de novo with a few cases of malignant transformation of ameloblastomas. Although rare, these lesions have been known to metastasize, mostly to the regional lymph nodes or lungs. Here we reported a case of 62year old male and his clinical, radiographical and histological features has been discussed with an insight on the classification systems of odontogenic malignancies.

Profiling of antioxidant superoxide dismutase in saliva of oral submucous fibrosis patients to categorize its diagnosis in varying stages

Oral submucous fibrosis is a premalignant condition in Indian and South-East Asia. Role of oxidant-antioxidant in causation and progression of cancer and pre cancers is known. Reactive oxygen species are generated in the oral cavity during chewing areca nut, the major etiological agent in oral submucous fibrosis. To see the alterations in the salivary superoxide dismutase levels in various clinical and histopathological grades of oral submucous fibrosis. Unstimulated saliva was collected from 25 oral submucous fibrosis patients and age and gender matched controls. The saliva was assessed for superoxide dismutase value by spectrophotometric method using assay kit [Bio Vision Catalog # K335-100]. The oral submucous fibrosis cases were grouped into clinical stages and histopathological grades and superoxide dismutase values were compared in different clinical stages and histopathological grades. The superoxide dismutase levels were reduced in oral submucous fibrosis as compared to controls. A steady decline in the levels was seen as the clinical stage and histopathological grade of oral submucous fibrosis advanced. Salivary superoxide dismutase levels can be alternatively used as a surrogate marker for the diagnosis of oral submucous fibrosis. Oral physicians should advise the pan chewers to regularly check their salivary superoxide dismutase levels so as to ease the early diagnosis of oral submucous fibrosis